Abstract Francesc F?brega Bonadona
Physiologically based pharmacokinetic (PBPK) models are mathematic representations of the human body that aims to assess the time course distribution of chemicals in human tissues. PBPK models may improve the assessment of human health risk but until now were not well studied. Among the most harmful environmental pollutants for human health there are polychlorinated dibenzo-p-dioxins and polychlorinated dibenzofurans (PCDD/Fs) and perfluoroalkyl substances (PFASs).
The objective of the present work is to develop a PBPK model to assess the time course concentration of PCDD/Fs and PFASs in human tissues.
Previously to the PBPK model development, a ranking index was developed using self-organizing maps (SOM) to assess the most harmful environmental contaminants, being PFASs among the most harmful compounds. After that, the PBPK model was developed to assess and predict the concentration of PCDD/Fs in human blood and adipose tissue. The final outcomes were very coincident with the experimental data found in Tarragona County (NE of Spain), and the model was considered as a validated. After that, the model was adapted to assess the concentrations of PFASs. Firstly the model was developed for PFOS and PFOA, that are the most studied compounds in the research literature, and then the model was expended to 9 PFASs more. Finally the uncertainty analysis of the PBPK model was conducted, and the parametric uncertainty was visually and statistically studied.
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