Biomaterials and biofabrication in tissue engineering: progress and challenges

Aldo R. Boccaccini (University of Erlangen-Nuremberg, Germany)

Location: Sala de Graus, ETSEQ
Start time: Jan. 22, 2016, 12 p.m.

Abstract

The development of multifunctional bioactive materials, focusing on bioactive glasses, for tissue engineering and regenerative medicine will be discussed, summarizing the progress made and the remaining challenges for the future. A comprehensive overview about 3D scaffolds will be presented and key results on the development of (nanostructured) bioactive glass and polymer-bioactive glass composite scaffolds will be discussed. Novel approaches involving the coating and infiltration of scaffolds by biodegradable polymers containing functionalized nanoscale particles or nanofibres for in-situ drug delivery will be introduced, as an attractive concept to merge tissue engineering and drug delivery approaches. To highlight the important advantage of bioactive glasses in comparison with other biomaterials, we will discuss how specific glass compositions doped with bioinorganics (metallic ions with therapeutic effects) can induce favourable cell behaviour in relation to osteogenesis and angiogenesis. In this context, the vascularisation potential of a new family of bioactive scaffolds incorporating biologically active ions will be discussed and the current challenge in the field, e.g. the development of vascularised tissues, will be demonstrated based on recent in vivo results. Areas of future research in the field of biomaterials for engineering (complex) tissue interfaces, e.g. osteochondral defects, and for wound healing and soft tissue regeneration will be discussed introducing the concept of cell encapsulation and biofabrication (processing with cells). Finally, the author’s views about the challenges ahead will be presented, focusing on open issues that must be tackled to translate current tissue engineering approaches to clinical settings.

Email announcement

About Aldo R. Boccaccini

Institution: University of Erlangen-Nuremberg, Germany

Prof. Dr.-Ing. habil. Aldo R. Boccaccini is Professor of Biomaterials and Head of the Institute of Biomaterials at the Department of Materials Science and Engineering, University of Erlangen-Nuremberg, Germany.

Prior to this appointment, he was Professor of Materials Science and Engineering at Imperial College London, UK (2000-2009).
He has remained Visiting Professor of Materials at Imperial College London.

He is also visiting professor at Nagoya Institute of Technology (Japan), RWTH Aachen University (Germany) and Universidad Nacional de Cuyo (Argentina).

Boccaccini holds a MEng degree from Instituto Balseiro (Argentina), PhD (Dr-Ing.) from RWTH Aachen University (Germany) and Habilitation from Ilmenau University of Technology (Germany).

Before joining Imperial College in 2000, he had appointments at the University of Birmingham (UK), the University of California at San Diego (USA) and the Ilmenau University of Technology, Germany.

The research activities of Prof. Boccaccini are in the broad area of glasses, ceramics and polymer/glass composites for biomedical, functional and/or structural applications.
Prof. Boccaccini has also developed the electrophoretic deposition technique for production of nanostructured materials and composites with defined surface topography with potential use in the biomedical field.

He is the author or co-author of more than 450 scientific papers and 15 book chapters.

Boccaccini is Fellow of the Institute of Materials, Minerals and Mining (UK) and of the American Ceramic Society.
He is the Editor-in-Chief of the journal “Materials Letters” (Elsevier) and serves in the editorial board of several recognized international journals including Journal of Materials Science, J. Tissue Engineering and Regenerative Medicine, International Materials Review, J. Biomaterials Applications, Advanced Engineering Materials, Advances in Applied Ceramics, Key Engineering Materials and J. Mater. Processing Technology.

He has been a visiting professor at different universities around the world, including Japan, Italy, Singapore, Germany, Argentina, Poland. Boccaccini has been member of the organizing committee of numerous international conferences and he is the founder of the International Conferences Series on Electrophoretic Deposition (sponsored by Engineering Conferences International) having served as the Chairman of the 4 conferences of the series held so far in Canada (2002), Italy (2005), Japan (2008) and Mexico (2011).

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